Delle Sedie A
Working group OMERACT > GOUT
Maria-Antonietta D’Agostino & LENE TERSLEV
Objective of the subgroups work:
Development of US scoring systems for Gout, including structure and crystal depositon. Assumed synovitis RA work will apply.
Investigation of reliability, and when reliable
Truth, Discrimination and feasibility
After obtaining step 1-3, try endorsement of instrument
What is the contribution of the subgroup work to the OMERACT work?
Inner circle :tophus burden
Middle circle; joint damage, joint inflammation
The US working groups work have contributed to the gout working group indicating that US is likely to be of use in assessing these domains, and endorsing a research agenda.
Description of the previous work
Delphi; agreement on elementary lesions, DC, tophi, aggregates, erosions
Web based reliability exercise
Patient based reliability exercise
Validation against DECT, results pending
Reporting back of work done since ACR 2017
Helen Keen undertaking validity work of the DC and tophi in cadavers
OMERACT fellow, Sara Nysom, is validating sensitivity to change – will be presented at the meeting
MADA the DECT work.
Next steps and discussion points
Continued work on the defining aggregates ( poor reliability), and demonstrating discrimination.
Development of a scoring system
Terslev L, Gutierrez M, Schmidt WA, Keen HI, Filippucci E, Kane D, Thiele R, Kaeley G, Balint P, Mandl P, Delle Sedie A, Hammer HB, Christensen R, Möller I, Pineda C, Kissin E, Bruyn GA, Iagnocco A, Naredo E, D’Agostino MA; OMERACT Ultrasound Working Group. Ultrasound as an Outcome Measure in Gout. A Validation Process by the OMERACT Ultrasound Working Group. J Rheumatol. 2015;42:2177-81.
Gutierrez M, Schmidt WA, Thiele RG, Keen HI, Kaeley GS, Naredo E, Iagnocco A, Bruyn GA, Balint PV, Filippucci E, Mandl P, Kane D, Pineda C, Delle Sedie A, Hammer HB, Christensen R, D’Agostino MA, Terslev L; OMERACT Ultrasound Gout Task Force group. International Consensus for ultrasound lesions in gout: results of Delphi process and web-reliability exercise. Rheumatology (Oxford). 2015;54:1797-805.
Terslev L, Gutierrez M, Christensen R, Balint PV, Bruyn GA, Delle Sedie A, Filippucci E, Garrido J, Hammer HB, Iagnocco A, Kane D, Kaeley GS, Keen H, Mandl P, Naredo E, Pineda C, Schicke B, Thiele R, D’Agostino MA, Schmidt WA; OMERACT US Gout Task Force. Assessing Elementary Lesions in Gout by Ultrasound: Results of an OMERACT Patient-based Agreement and Reliability Exercise. J Rheumatol. 2015;42:2149-54.